Treatment-resistant depression or refractory depression is a term used in clinical psychiatry which refers to a major depression type which did not respond or react to two or more anti-deprssants. According to some experts the depression will be called treatment-resistant depression only if will not respond after the use of four different types of antidepressants.
There are lots different types of anti-depressants and when you try two or more different anti-depressants and still the depression isn’t controlled or gone then that doesn’t mean that the administered drugs are not effective. In this condition you need to try an anti-depressant of another class. You can also try the different drug of the the same class too.
Treatment-resistant depression can leave a person hopeless and frustrating. A long time can go by without any improvement or relief. But if the depression treatment isn’t working you shouldn’t give up. You with the help of your doctor just need to find another different approach. This may include other drugs, therapy and other treatments.
It is found that MAOI (Monoamine Oxidase Inhibitor) antideprssants are very effective and useful in the treatment of refractory depression or the treatment-resistant depression. But there are some dietary limitations while using these MAOIs. However these are found to be working in severe cases of refractory depression.
If the anti-depressants aren’t working then psychotherapy can be helpful. There are many types of psychotherapy and the most common type is cognitive psychotherapy. The expertise of therapist also plays an important role. If the therapist has a good personality and knows well how to make good relations with the patient, then you can expect excellent results.
There are many different types of drugs that are used in the treatment of refractory depression or treatment-resistant depression. The most common type of drugs are antidepressants. The other type of drugs are antipsychotic drugs. These drugs are given when there are psychological problems or reasons for the depression. But it is observed that there are severe side effects associated with the use of these drugs.
It is seen that some people feel a good relief from the depression with the use of a particular drug, in the very first time. But some other people with the same symptoms don’t feel well with the constant use of the same drug. The exact reason of this behaviour is not confirmed. But it is confirmed that old and severe types of depression are not easier to be treated. This is why it is always recommended to start the treatment of refractory depression or treatment-resistant depression as early as possible.