It is necessary to consider Tramadol’s elimination half-life to understand how long it is likely to stay in your system after stopping. The average amount of time it takes for 50% of the drug to be cleared from your system is the elimination half-life.
Tramadol’s elimination half-life is around 6.3 hours per indications found in the medical literature. This puts complete elimination time at around 35 hours. This means that it is likely to be eliminated from your system after roughly 1 day and 11 hours from the time you have last taken the drug.
‘O-desmethyltramadol’ the primary metabolite of tramadol, has a slightly longer half-life duration of 7.4 hours which should be noted. This means that elimination from your body will be after about 41 hours. A safe conclusion is that the drug and its primary metabolite will be gone from your system 48 hours after you last take a dose of Tramadol.
Tramadol will show up on urine drug tests for 2-4 days after use. However, Tramadol may show up a for a few days after last dose with heavy and chronic use. But in most cases, if someone hasn’t taken the drug within 48 hours, the levels are undetectable.
How long does tramadol stay in urine, blood, saliva and hair follicle drug tests ?
- Urine : For up to 2-4 days
- Blood : Up to 6 hours
- Saliva : For 1-4 days
- Hair follicle : For up to 90 days
Note that the numbers given above are only on average. Certain factors both individual and otherwise, do have a bearing on how long Tramadol is going to be in your system. Of paramount importance are factors such as the dosage itself, whether it was of the IR or ER variety, and the frequency of dosage. Age, fat percentage, metabolic rate and urinary pH genetics, liver and kidney functions and height-weight ratio also need to be taken into consideration as individual factors.
How long Tramadol stays in your system is influenced by certain variables
Among elderly patients compared to healthy adults, the half-life of Tramadol is hypothesized to increase. Interference with drug metabolism may result from reduced hepatic blood flow exhibited by elderly individuals, or from other medications they may be taking.
In addition, because of old-age, elderly individuals have other health problems and decreased physiologic efficiency compared to younger adults. This results in slower excretion.
- Body mass + Body fat (%):
Considering a person’s body mass when estimating how long Tramadol is likely to remain in their system may be helpful. Usually, in relation to the dosage of Tramadol they’ve taken, the greater a person’s body mass (height/weight) – they will excrete the drug quicker from their body.
Conversely, in respect to the ingested Tramadol dose, the lesser a person’s body mass – the efficiency of metabolization and excretion is likely to be less.
- Food intake + Hydration:
The time taken for absorption of Tramadol could be affected if you took your last dose of with food. Because the body is simultaneously working to breakdown food, a large meal along with Tramadol is thought to delay its absorption. When your body takes slightly longer to eliminate the drug because it wasn’t absorbed as quickly, that is the meaning of delayed absorption
- Hepatic + Renal function:
Prior to excretion, Tramadol is processed by the kidneys and extensively metabolized by enzymes within the liver. The half-life elimination of Tramadol may increase should an individual exhibit hepatic impairment. That is, the drug and its metabolites because of the liver’s impaired function may take longer to “break down”.
- Metabolic rate:
Following your last dose, a person’s basal metabolic rate (BMR) may influence the duration over which Tramadol remains in systemic circulation.
Metabolization and excretion of drugs (and other exogenous substances) specifically often occur faster in those with high BMRs. The opposite is true regarding individuals with low BMRs. More efficient drug metabolism and excretion indicates more energy burning at rest, typical of high BMRs.
Genes responsible for influencing hepatic enzymes, can affect the pharmacokinetics of Tramadol. It is necessary to understand these genetic variants. Variants of CYP2D6 alleles may affect both clearance speed and elimination half-life since the drug is chiefly metabolized by CYP2D6 isoenzymes to form O-desmethyltramadol.
Impacting how long Tramadol stays in your system are variations in other enzymes CYP3A4 and CYP2B6. This is true to a lesser extent with CYP2D6.
- Urinary pH:
Urinary excretion in the form of metabolites eliminates most of a Tramadol dose. The pH of a person’s urine influences urinary drug clearance. This effect has been suggested by some research. Greater alkalinity of a person’s urine specifically results in a longer retention prior to excretion of drug metabolites.
2. Dosage (Low vs. High)
The length of time Tramadol remains in a person’s system is influenced by the dosage of Tramadol that they take.
A greater burden is placed on hepatic isoenzymes for metabolism at higher doses. Additionally, prior to excretion, higher doses also result in a conversion to increased numbers of metabolites. Consequently, a person taking a higher dose of the drug (e.g. 300 mg per 24 hours) will metabolize the drug at a slower rate. This is due to the increased amount. Compared to a low dose user, more metabolites necessitate more clearance.
3. Term of Administration
How long Tramadol is likely to stay in a person’s system is affected by both the frequency of its administration and the period over which it is taken.
Immediate-release (IR) Tramadol (taken by someone on an “as-needed,” intermittent basis) is excreted quicker than someone taking a once daily dose of extended-release (ER) Tramadol. With most Tramadol users taking the 24-hour “ER” format, the term of administration typically has less of an influence on frequency of usage than excretion.
4. Co-ingestion of other drugs
Pharmacokinetics of Tramadol may be altered if you’re taking other drugs along with it. The metabolism of Tramadol is primarily through CYP2D6 forming “O-desmethyltramadol” (M1), its most prominent metabolite.
The functionality of CYP2D6 isoenzymes interacting with other drugs could influence Tramadol’s elimination half-life. Less efficient metabolism and impaired clearance may occur because of interference with CYP2D6 function by drugs known as CYP2D6 inhibitors.